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Toby,anawkwardOCDphysicsgenius,andKara,ahotex-Catholicsororitygirl,wakeupafterblackingoutHalloweennighttodiscovertheymissedtheevacuationofEarth.Amysteriousagentpursuesthefeudingcoupleastheyfigureouthowtoworktogethertosolvetherecentlyentangledmulti-verseandultimatelysavehumanity.Basedonrealscience,ManifestDestinyDown:Spacetimetakestheaudienceonawild,ridiculousrideintoQuantumMechanicsandreligion,andwherethetwoeventuallyseeeyetoeye.Aquirky"PhysicsforDummies,"withreallessonsalongtheway,thestorystartsoutwiththerecentandveryrealdiscoverybyCERNofwhat'sknownas"TheGodParticle"-themissinglinkinthestandardmodelofQuantumMechanics.ThegreatestchallengeofourscientifictimesisthatthephysicsofEinstein-thelargebodiesinoursolarsystem-doesnotconnecttothephysicsofthesmall,particlephysics,ultimatelyleavingagiantgapinourunderstandingoftheUniverse.Thus,scientistsforthepast100yearshavedesperatelysought"TheTheoryofEverything,"theoneequationwhichlinksthetwodiametricallyopposedunderstandingsofhowourrealityworks.TheGodParticlewaswidelyconsideredthemissingclue.Millionsofpeoplearoundtheworldtrackeveryannouncementrelatedtothesubject.Attheheartofthisstoryandthescienceisourperceptionoftime,theillusionofreality,andtheveryillogicalnotionthatwhatweseeisn'treallyreal.